A Study to Know the Effect of Antiepileptic Drugs on Liver Enzymes

Objective: To know the effect of antiepileptic drugs on liverenzymes.Study Design: Cross sectional study.Materials & Methods: The study was conducted on 108patients at SIMS Hapur and G.S Medical College Hapurbetween Jan 17 to Dec 17. Patients divided into 3 groups,consisting of 36 patients in each group of phenytoin,carbamazepine and valproate.Results: Total No. of Patients was 108, out of which 36patients were there is each group of Phenytoin,Carbamazepine and valproate. Most of the patients 36(33.33%) and 32 (29.62%) belongs to age group of >40 – 50years and >50 year respectively. Regarding raised SGPT, itwas seen in 5 (13.89), 3 (8.33) and 3 (8.33) in phenytoin,carbamazepine and sodium valproate group respectively.SGOT were raised in sodium valproate group respectively.Alkaline phosphatase were raised in 10 (27.78), 20 (55.56) and22 (61.11) in phenytoin group, carbamazepine group, andsodium valproate group respectively.Conclusion: From the present study we can conclude thatsodium valproate is more hepatotoxic than carbamazepinewhich is more toxic than phenytoin. It is recommended thatbase line Liver Function Test (LFT) is essential before startingof AEDs and regular monitoring of LFT is also done betweenthe course of treatment.

Neuropathy in cases of Hypothyroidism as Confirmed by Motor Nerve Conduction Studies: A Prospective Study in a Tertiary Care Hospital

Background: Thyroid hormone play important role in development of Central Nervous System and in myelination of neurons. Patients of hypothyroidism may suffer from peripheral nervous dysfunction. Aim of our study is to find out the neuropathy in hypothyroidism. Methods: This prospective study was conducted on 40 subjects, out of which n=20 were euthyroid control and n=20 were hypothyroid. The Study was performed in the Medicine department of Saraswathi Institute of Medical Sciences, Hapur in collaboration with the department of Physiology at G.S. Medical College, Hapur. MNCV and latency of Median, Ulnar, and Common Peroneal nerve of both upper and lower limb were done in patients of Hypothyroidism and in Control subjects. Results: Significant bilateral decrease is observed in the MNCV of the Median Nerve in Hypothyroid subjects as compared to the control subjects. Also, there  is Significant  bilateral  increase  in the  Motor Latency of the Median Nerve in Hypothyroid subjects as compared to the control subjects. Conclusion: Hypothyroidism cause significant decrease in MNCV of Median Nerve as well as increase in Motor latency in Median Nerve.